Age-Dependent Regeneration by Using Electromyographical Study Foliowing Sciatic Nerve Injury in Rat

Purpose: There are extensive evidences that show axonal processes of the nervous system (peripheral and/or central) may be degenerated after nerve injuries. Axonal regeneration is relation to various factors. In this investigation we decided to evaluate the effects of nerve regeneration age-dependent on injured rat sciatic nerv. Materials and Methods: For this study, the right sciatic nerve of 12 (2 groups, n=6) male Wistar rats (20 postnatal day and 6 month old) locally undergo the tense compression for 30 seconds in mid thigh region and the uncrushed left sciatic nerve was assumed as control. The conduction velocity of injured and intact sciatic nerves were determined during a period of 49 days. The electromyographical data were obtained from stimulation-response curves, using stimulation of the proximal part of the sciatic nerve and recording the electrical response in the plantar .muscles in each group. The stimulation response recrods were saved, analyzed and their conduction time were measured to compare crushed and uncrushed nerves in two groups (neonate and old rats). Results: The average conduction times neonates at the end of ths period showed a shorter latency records in comparison with old group. Conclusion: These results indicated that in neonate rats, conduction time was lower in comparison with adults and an accelerated regeneration rate of sciatic nerve was observed in early postnatal age.